At Longevity Clinic, we dedicate ourselves to your Health, Wellbeing and Beauty.
Here, science and advanced technology with personalized care, will help you improve your Healthspan, balance and happiness towards a more fulfilling life. A transformative journey of self-discovery, vitality, and longevity.
Healthspan and Lifespan
The discovery of the Hallmarks of Aging has revolutionized longevity science, allowing us to understand and intervene in the mechanisms that cause aging, preventing disease and promoting rejuvenation. It has forever transformed the way we understand and apply integrative medicine. At Longevity, we embrace this scientific framework as the foundation of everything we do to help those who seek us with the goal of optimizing both Healthspan and Lifespan, through diagnostics and therapies grounded in longevity science.
André Dourado
Head of Integrative Longevity
Biologist specializing in longevity, expert in natural and integrative medicine.
Professor of Integrative Medicine and Longevity, certified Naturopath and Osteopath with extensive experience in the fields of healthspan, performance, and oncology.
Longevity Medicine
Our Pillars reflect how our Longevity Medicine is structured to address how the Hallmarks of Ageing is impacting each individual
Preventive
Act early to protect your health and prevent disease
Personalised
Focus on the patient, not on the disease
Holistic
Analyse all factors that are impacting on the individual health and wellbeing
Integrative
Use all bodies of medical knowledge, modern and ancient, western and eastern, conventional and complementary
Regenerative
Restore vitality and youthfulness, by regenerating inflammatory processes and dysfunctions
Our Methodology
The RESTORE Methodology is your pathway to optimal wellness, beauty and health:
Reset • Evaluate • Support • Transform • Optimise • Regenerate • Elevate
From treatments, to journeys of protocols and programmes, find your own path and your level of engagement with Longevity Clinic.
12 Hallmarks of Ageing
The 12 Hallmarks of Ageing are like the key “problems” that scientists believe cause our bodies and cells to age. Think of them as 12 main reasons why we get older and our bodies start to wear down over time.
Here’s a simple breakdown of each hallmark with easy examples:
1. Genomic Instability
What it means:
Our DNA accumulates changes over time, and the repair mechanisms cannot always keep up with the damage.
Example
Like a book with torn pages or smudged words, our DNA can be damaged by sunlight, pollution, or normal cellular processes. Over time, this can increase the risk of diseases such as cancer.
2. Telomere Attrition
What it means:
Telomeres, the protective caps at the ends of chromosomes, gradually shorten as cells divide.
Example
Like the plastic tips on shoelaces wearing down, when telomeres become too short, cells can no longer divide properly and enter senescence (stop functioning).
3. Epigenetic Alterations
What it means:
Changes in gene expression caused by chemical modifications to DNA, without altering the DNA sequence.
Example
It’s like a piano being played with wrong notes — the piano (your DNA) is still there, but the music (gene expression) doesn’t sound right. This can affect how cells work.
4. Loss of Proteostasis
What it means:
Defective proteins accumulate as cellular repair and recycling systems fail.
Example
Proteins are like tools in a toolbox. If they get damaged or clump together (like in Alzheimer’s), the tools stop working properly.
5. Disabled Macroautophagy
What it means:
The body’s cellular “clean-up” system no longer works efficiently.
Example
Autophagy is like the recycling crew of your cells. If it stops cleaning up old parts, trash builds up and clogs everything, leading to ageing.
6. Mitochondrial Dysfunction
What it means:
The “power plants” of the cell (mitochondria) no longer produce energy efficiently.
Example
Imagine a factory running on old, broken generators — energy drops, and waste builds up. This makes us feel tired and contributes to ageing.
7. Deregulated Nutrient Sensing
What it means:
The body misinterprets signals about energy and nutrients.
Example
It’s like a car with a faulty fuel gauge — the body may think it needs more food or stores energy inefficiently, contributing to obesity, diabetes, and metabolic decline.
8. Cellular Senescence
What it means:
Some cells permanently stop dividing but remain active, releasing harmful signals.
Example
Like a retired worker hanging around the office and getting in the way, these “zombie” cells release chemicals that cause inflammation and damage.
9. Chronic Inflammation ("Inflammaging")
What it means:
Persistent, low-level inflammation throughout the body.
Example
Like a fire that never fully goes out — it may seem harmless at first, but over time it slowly damages tissues and organs.
10. Dysbiosis (Unbalanced Gut Microbiome)
What it means:
The beneficial bacteria in your gut become imbalanced, disrupting normal gut functions.
Example
Think of your gut as a garden. If weeds (bad bacteria) take over, digestion, immunity, and even brain health can be affected.
11. Stem Cell Exhaustion
What it means:
Stem cells, which repair and regenerate tissues, gradually lose their ability to function.
Example
Like a repair crew running out of workers, tissues can’t be fixed or renewed properly, leading to aging and impaired organ function.
12. Altered Intercellular Communication
What it means:
Cells don’t “talk” to each other properly anymore.
Example
Imagine a group project where team members stop sharing info — the whole project (your body) falls apart faster, and inflammation can spread.
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